The Glutathione Man
Riboceine
The Glutathione Man
 

 

PRUVN Announces Human Clinical Trial Findings on the Impact of Max International RiboCeine™ Supplementation on Serum Glutathione Levels - 25th April 2024

PRUVN Human Clinical Trial on RiboCeine™ and Serum Glutathione Levels
A human clinical trial conducted by PRUVN Research LLC has provided important evidence on the impact of Max International’s patented RiboCeine™ supplementation on serum glutathione levels.
This double-blind placebo-controlled study was ethically approved and involved 40 participants aged between 38 and 60 who were randomly assigned to receive either a daily 250 mg dose of RiboCeine™ or a placebo over a four-week period. Serum glutathione levels were measured before and after supplementation using a standard spectrophotometric assay.

Key Findings from the Trial

  • Participants in the placebo group experienced a decrease in serum glutathione levels over the course of the study.

  • The group receiving RiboCeine™ showed a significant 26.6 % increase in serum glutathione levels overall.

  • The effect was especially notable in the older age group (51-60), where serum glutathione increased by 64.7 %.

  • These results suggest that RiboCeine™ can effectively elevate glutathione levels in humans with pronounced benefits seen in mature adults.

While this preliminary study highlights promising trends in supporting the body’s natural antioxidant capacity more research with larger participant numbers is recommended to further validate the findings.

This study marks a significant step in translating decades of preclinical research into meaningful evidence of RiboCeine™’s role in enhancing glutathione production in real-world settings.

 

Dr Herbert T Nagasawa explains about The Science of Riboceine™
 
RiboCeine™
For many decades scientists and medical professionals have recognised Glutathione as the body’s most powerful internal defender. It functions as the master antioxidant and a key detoxifier produced naturally within our cells. However, under constant oxidative stress and with advancing age particularly from around 40 the body’s ability to generate sufficient Glutathione begins to decline.

Earlier approaches such as N-acetyl-cysteine (NAC) provided partial support yet came with clear limitations. This changed with a major scientific breakthrough led by the late Dr Herbert T Nagasawa. His work resulted in the development of RiboCeine™ a patented compound designed to deliver Cysteine to cells with greater efficiency allowing the body to naturally increase its own Glutathione production in a more effective and sustainable way.

Max International is the proud holder of the United States Patent for RiboCeine™. This innovation is supported by decades of scientific research plus real world application, making it one of the most advanced Glutathione supporting technologies available today.

RiboCeine™ represents a smarter approach to cellular protection detoxification and long term wellness from within.
 

Scientifically Proven and Patented Technology
 RiboCeine™ is a scientifically engineered molecule created from Ribose and Cysteine both of which are naturally present in the body. After consumption RiboCeine™ is efficiently absorbed into the bloodstream where it delivers these critical nutrients directly into the cells. This targeted delivery supports the body’s natural production of Glutathione while also supplying Ribose an essential component in the formation of ATP the primary energy currency of every cell.

In multiple scientific comparisons RiboCeine™ has consistently demonstrated superior performance when measured against other Glutathione supporting approaches. To date it has been featured in more than 60 peer reviewed scientific studies many of which were supported by the National Institutes of Health plus other respected research institutions. These studies reinforce both its effectiveness and its innovative design.

Explore the Science Behind RiboCeine™
Gain access to an extensive body of knowledge including over 60 published studies focused on RiboCeine™. These studies explain how RiboCeine™ functions at the cellular level to enhance the body’s own Glutathione production. Its unique mechanism of action ensures that essential building blocks are delivered directly into cells distinguishing it clearly from conventional supplementation methods.

Independent peer reviewed research published on trusted third party scientific platforms allows you to examine the evidence firsthand. These validated findings highlight RiboCeine™’s proven ability to elevate Glutathione levels strengthen cellular defences and support overall cellular health.
 
  1. Roberts, J.C.; Nagasawa, H.T.; Zera, R.T.; Fricke, R.F.; Goon, D.J. W. Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(polyhydroxyalky)-and 2-(Polyacetoxyalky)-Thiazolidine-4(R)-Carboxylic Acids. J. Med Chem. 1987, 30, 1891-1896.
  2. Roberts, J.C.; Francetic, D.J.; Zera, R.T. L-cysteine prodrug protects against cyclophosphamide urotoxicity without compromising therapeutic activity. Cancer Chemotherapy and Pharmacology 1991, 28, 166-170.
  3. Roberts, J.C.; Francetic, D.J. Time course for the elevation of glutathione in numerous organs of L1210-bearing CDF1 mice given the L-cysteine prodrug, RibCys. Toxicology Letters, 1991, 59, 245-251.
  4. Roberts, J.C.; Francetic, D.J. Mechanisms of Chemoprotection by RibCys, a Thiazolidine Prodrug of L cysteine. Med. Chem. Res., 1991, 1, 213-219.
  5. Roberts, J.C.; Charyulu, R. L.; Zera, R.T.; Nagasawa, H.T. Protection Against Acetaminophen Hepatotoxicity by Ribose-Cysteine (RibCys). Pharmacology & Toxicology, 1992, 70, 281-285.
  6. Rowe, J.K.; Zera, R.T.; Madoff, R.D.; Fink, A.S.; Roberts, J.C.; Johnston, G.R.; Freeney, D.A.;Young, H.L.; Bubrick, M.P. Protective Effect of RibCys Following High-Dose Irradiation of the Rectosigmoid. Dis. Colon Rectum, 1993, 36(7), 681-687.
  7. Roberts, J.C.; Francetic, D.J.; Zera, R.T. Chemoprotection against Cyclophosphamide-Induced Urotoxicity: Comparison of Nine Thiol Protective Agents. AntiCancer Research, 1994, 14, 389-396.
  8. Carroll, M.P.; Zera, R.T.; Roberts, J.C.; Schlafmann, S.E.; Feeny, D.A.; Johnston, G.R.; West, M.A.; Bubrick, M.P. Efficacy of Radioprotective Agents in Preventing Small and Large Bowel Radiation Injury. Dis. Colon Rectum, 1995, 38(7), 716-722.
  9. Roberts, J.C.; Koch, K.E.; Detrick, S.R.; Warters, R.L.; Lubec G. Thiazolidine Prodrugs of Cysteamine and Cysteine as Radioprotective Agents. Radiation Research, 1995, 143, 203-213.
  10. Bantseev, V.; Bhardwaj, R.; Rathbun, W.; Nagasawa, H.T.; Trevithick, J.R. Antioxidants and Cataract: (Cataract Induction in Space Environment and Application to Terrestrial Aging Cataract). Biochem. Mol. Bio. Intl., 1997, 42, 1189-1197.
  11. Roberts, J.C.; Phaneuf, H.L.; Szakacs, J.G.; Zera, R.T.; Lamb, J.G.; Franklin, M.R. Differential Chemoprotection against Acetaminophen-Induced Hepatotoxicity by Latentiated L-Cysteines. Chem. Res. Toxicol., 1998, 11, 1274-1282.
  12. Roberts, J.C.; Phaneuf, H.L.; Dominick, P.K.; Wilmore, B.H.; Cassidy, P.B. Biodistribution of [35S] – Cysteine and Cysteine Prodrugs: Potential Impact on Chemoprotection Strategies. J. Labelled Cpd. Radiopharm., 1999, 42, 485-495.
  13. Lucus, A.M.; Henning G.; Dominick, P.K.; Whiteley, H.E.; Roberts, J.C.; Cohen, S.D. Ribose Cysteine Protects Against Acetaminophen-Induced Hepatic and Renal Toxicity. Toxicologic Pathology, 2000, 28(5), 697-704.
  14. Wilmore, B.H.; Cassidy, P.B.; Warters, R.L.; Roberts, J.C. Thiazolidine Prodrugs as Protective Agents against γ-Radiation-Induced Toxicity and Mutagenesis in V79 Cells. J. Med. Chem., 2001, 44(16), 2661-2666.
  15. Lenarczyk, M.; Ueno, A.; Vannais, D.B.; Kraemer, S.; Kronenberg, A.; Roberts, J.C.; Tatsumi, K.; Hei, T.K.; Waldren, C.A. The “Pro-drug” RibCys Decreases the Mutagenicity of High-LET Radiation in Cultured Mammalian Cells. Radiation Research, 2003, 160, 579-583.
  16. Waldren, C.A.; Vannais, D.B.; Ueno A.M. A role for long-lived radicals (LLR) in radiation-induced mutation and persistent chromosomal instability: counteraction by Ascorbate and RibCys but not DMSO. Mutation Research. 2004, 551:255-265.
  17. Lucas Slitt, A.M.; Dominick, P.K.; Roberts, J.C.; Cohen, S.D. Effect of Ribose Cysteine Pretreatment on Hepatic and Renal Acetaminophen Metabolite Formation and Glutathione Depletion. Basic Clin. Pharmacol. Toxicol., 2005, 96 (6), 487-94.
  18. Oz, H.S.; Chen, T.S.; Nagasawa, H., Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model. Translational Research, 2007, 150(2), 122-129.
  19. Oz, H.S. and Ebersole, J.L. Application of Prodrugs to Inflammatory Diseases of the Gut. Molecules, 2008, 13, 452-474
  20. Walker R.B., Everette J.D. Comparative Reaction Rates of Various Antioxidants with ABTS Radical Cation. J. Agric Food Chem. 2009:57:1156-1161.
  21. Heman-Ackah, S.E.; Juhn, S.K.; Huang, T.C.; Wiedmann, T.S. A combination antioxidant therapy prevents age-related hearing loss in C57BL/6 mice. Otolaryngology-Head and Neck Surgery, 2010, 143, 429-434.
  22. Jurkowska, H.; Uchacz, T.; Roberts, J.; Wrobel, M. Potential therapeutic advantage of ribose-cysteine in the inhibition of astrocytoma cell proliferation. Amino Acids, 2011 41, 131-139.
  23. Kader, T.; Porteous C.M.; Williams M.J.A.; Gieseg, S.P.; McCormick, S.P.A. Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice. Atherosclerosis. 2014, 237, 725-733.
  24. Saltman A.E. D-Ribose-L-cysteine supplementation enhances wound healing in a rodent model. Am J Surg. 2015, 210, 153-158.
  25. Falana B, Adeleke O, Orenolu M, Osinubi A, Oyewopo A. Effect of D-ribose-L-cysteine on aluminum induced testicular damage in male Sprague-Dawley rats. JBRA Assisted Reproduction. 2017:21(2):94-100.
  26. Joseph D.B., Olayemi O.S., Falana B.A., Duru F.I.O. Osinubi A.A.A. D-Ribose-L-Cysteine Maintained Testicular Integrity in Rats Model (Rattus Novergicus) Exposed to X-Ray. Nuclear Medicine. 2017(2)4:20-26.
  27. Ogunlade B., Osinubi A.A., Duru F.I.O., Adelakun S.A., Ogunlade S.A., Alao A.A, Histomorphological Response of Sulforaphane and RiboCeine on Annular Puncture-Induced Model of Rabbits Intervertebral Disc Degeneration. European Journal of biomedical and Pharmaceutical Sciences. 2017(4)11:1-9.
  28. N’guessan B.B., Amponsah S.K., Dugbartey G.J., Awuah K.D., Dotse E., Aning A., Kukuia K.K.E., Asiedu-Gyekye I.J., Appiah-Opong R. In Vitro Antioxidant Potential and Effect of a Glutathione-Enhancer Dietary Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity. Evidence-Based Complementary and Alternative Medicine. 2018:7462839:8 pages.
  29. Awodele O, Badru W.A., Busari A.A., Kale O.E., Ajayi T.B., Udeh R.O. Emeka P.M. Toxicological evaluation of therapeutic and supra-therapeutic doses of Cellgevity on reproductive function and biochemical indices in Wistar rats. BMC Pharmacology and Toxicology. 2018:19:68.
  30. Cukrov D., Newman T.A.C., Leask M., Leeke B., Sarogni P., Patimo A., Kline A.D., Krantz I.D., Horsfield J.A., Musio A. Antioxidant treatment ameliorates phenotypic features of SMC1A-mutated Cornelia de Lange syndrome in vitro and in vivo. Human Molecular Genetics. 2018:27:17:3002-3011.
  31. Osinubi A.A.A, Medubi L.J., Akang E.N., Sodiq L.K., Samuel, T.A., Kusemiju T., Osolu J., Madu D., Fasanmade O. A comparison of the anti-diabetic potential of D-ribose-L-cysteine with insulin, and oral hypoglycaemic agents on pregnant rats. Toxicology Reports. 2018(5):832-838.
  32. Medubi L.J., Ama C., Medubi O.O., Onwosu N.C., Lawal O.R., Osinubi A.A.A. D-Ribose-L-Cysteine-Rich Supplement Attenuates Doxorubicin-Induced Impaired Spermatogenesis, Testicular Steroidogenesis and Redox Status in Sprague-Dawley Rats. African Journal of Biomedical Research. 2019(22):179-185.
  33. Emokpae O, Ben-Azu B, Ajayi AM, Umukoro S. D-Ribose-L-Cysteine attenuates lipopolysaccharide-induced memory deficits through inhibition of oxidative stress, release of proinflammatory cytokines, and nuclear factor-kappa B expression in mice. Naunyn-Schmiedeberg’s Archives of Pharmacology. 07 January 2020.
  34. Kader T., Porteous M., Jones G., Dickerhof N., Narayana V.K., Taraknath S., McCormick S.P.A. Ribose-Cysteine protects against the development of atherosclerosis in apoE-deficient mice. PLoS ONE 15(2): e0228415. 02 21 2020.
  35. Emokpae O, Ben-Azu B, Ajayi AM, Umukoro S. D-Ribose-L-Cysteine enhances memory task, attenuates oxidative stress and acetyl-cholinesterase activity in scopolamine amnesic mice. Drug Dev Res. 2020;1-9
  36. Amponsah S.K., N’guessan B.B, Akandawen, A.A., Agboli S.Y., Danso, E.A., Opuni K.F.M., Asiedu Gyekye I.J., Appiah-Opong, R. Effect of Cellgevity Supplementation on Selected Rat Liver Cytochrome P450 Enzyme Activity and Pharmacokinetic Parameters of Carbamazepine. Evidence-Based Complementary and Alternative Medicine. Volume 2020 (July 3), Article ID: 7956493, 8 pages.
  37. Okoh, L., Ajayi, A.M., Ben-Azu, B., Akinluyi, E.T., Emokpae, O., Umukoro, S. D-Ribose-L-Cysteine exhibits adaptogenic-like activity through inhibition of oxido-inflammatory responses and increased neuronal caspase-3 activity in mice exposed to unpredictable chronic mild stress. Molecular Biology Reports. 2020 47:7709-7722.
  38. Ogunlade, B., Gbotolorun S.C., Ogunlade, A.A. D-Ribose-L-Cysteine modulates lead acetate-induced hematobiochemical alterations, hormonal imbalance, and ovarian toxicity in adult female Wistar rats. Drug and Chemical Toxicology. November 7, 2020; 1-8.
  39. Ogunlade, B., Fidelis, O.P., Afolayan, O.O., Agie, J.A. Neurotherapeutic and antioxidant response of D Ribose-L-Cysteine nutritional dietary supplements on Alzheimer-type hippocampal neurodegeneration induced by cuprizone in adult male wistar rate model. Food and Chemical Toxicology. November 11, 2020; 1-9.
  40. Oludare, G.O., Afolayan, G.O., Semidara, G.G. Potential anti-toxic effect of d-ribose-l-cysteine supplement on the reproductive functions of male rats administered cyclophosphamide. J. Basic Clin Physiol Pharmacol. 2021 Feb 8.
  41. Ojetola, A.A., Adedeji, T.G., Fasanmade, A.A. Changes in antioxidants status, atherogenic index and cardiovascular variables after prolonged doses of D-ribose-L-cysteine in male Wistar rats. Heliyon 7 (2021) e06287.
  42. Medubi, L.J., Nwosu, N.C., Medubi, O.O., Lawal, O.R., Ama, C., Kusemiju, T.O., Osinubi, A.A.A. Increased de novo glutathione production enhances sexual dysfunctions in rats subjected to paradoxical sleep deprivation. JBRA Assisted reproduction. September 30, 2020; 1-8.
  43. Verrilli, A.M, Leibman, N.F., Hohenhaus, A.E., Mosher, B.A. Safety and efficacy of a ribose-cysteine supplement to increase erythrocyte glutathione concentration in healthy dogs. AJVR. 2021; 82(8). 653- 658.
  44. Ogunlade, B., Adelakun, S.A., Ukwenya, V.O., Elemoso, T.T. Potentiating response of D-Ribose-L Cysteine on Sodium arsenate-induced hormonal imbalance, spermatogenesis impairments and histomorphometric alterations in adult male Wistar rat. JBRA Assisted Reproduction. 2021; 25(3): 358- 367.
  45. Ojetola, A.A, Adeyemi, W.J., David, U.E., Ajibade, T.O., Adejumobi O.A., Omobowale, T.O., Oyagbemi, A.A., Fasanmade, A.A. D-ribose-L-cysteine prevents oxidative stress and cardiometabolic syndrome in high fructose high fat diet fed rats. J.Biopha. 2021 (142) 112017.
  46. Akingbade G.T., Ijomone O.M., Imam A., Aschner M., Ajao M.S. D-Ribose-l-Cysteine Improves Glutathione Levels, Neuronal and Mitochondrial Ultrastructural Damage, Caspase-3 and GFAP Expressions Following Manganese-Induced Neurotoxicity. 2021 Sep 4. doi: 10.1007/s12640-021- 00404-3. pp 1-13.
  47. Adelakun, S.A., Ogunlade, B., Iteire K.A., Adedotun, O.A. Ameliorating potential and fertility enhancing activities of nutritional dietary supplementation of D-Ribose-L-Cysteine in cisplatin induced oligoasthenoteratozoospermia and seminiferous epithelium degeneration in adult male Sprague-Dawley rats. Metabolism Open. 12 (2021) 100128.
  48. Leask, M., Carleton, C., Leeke, B., Newman, T., Antoun, J., Farella, M., Horshield, J. RiboCeine Rescues Auranofin-Induced Craniofacial Defects in Zebrafish. Antioxidants. 2021, 10, 1964.
  49. Akingbade G.T., Ijomone O.M., Imam A., Aschner M., Ajao A.S., D-Ribose-L-Cysteine attenuates manganese-induced cognitive and motor deficit, oxidative damage, and reactive microglia activation. Environmental Toxicology and Pharmacology. 2022.
  50. Ojetola, A.A. and Fasanmade, A.A. Ameliorative potential of D-Ribose-L-Cysteine in male Wistar rats with metabolic syndrome. FASEBJ. 2022, 35, May 2022.
  51. Isabor, H., Ajayi, A.M., Ben-Azu, B., Omeiza, N.A., Ademola, A.P., Umukoro, S. D-ribose-L-cysteine reduces oxidative stress and inflammatory cytokines to mitigate liver damage, and memory decline induced by copper sulfate in mice. Journal of Trace Elements in Medicine and Biology. 73 (2022) 127001.
  52. Ogunlade, B., Gbotolorun, S.C., Ogunlade, A.A. D-ribose-L-cysteine modulates lead acetate-induced hematobiochemical alternations, hormonal imbalance, and ovarian toxicity in adult female Wistar rats. Drug and Chemical Toxicology. 2022 45(4), 1606-1613.
  53. Adekomi,D.A, Olajide, O.J., Adewale, O.O., Okesina, A.A., Fatoki, J.O., Falana, B.A. Adeniyi, T.D., Adegoke A.A., Ojo, W.A., Alabi, S.O. D-ribose-L-Cysteine exhibits neuroprotective activity through inhibition of oxido-behavioral dysfunctions and modulated activities of neurotransmitters in the cerebellum of Juvenile mice exposed to ethanol. Drug Chem. Toxicol. 2022 June 20:1-11.
  54. Mega, O.O., Edesiri, T.P., Victor, E., Kingsley, N.E., Rume, R.A., Faith, F.Y., Simon, O.I., Oghenetega, B.O., Agbonito-Chijiokwu, E. d-ribose- l-cysteine abrogates testicular maladaptive responses induced by polychlorinated bisphenol intoxication in rats via activation of the mTOR signaling pathway mediating inhibition of apoptosis, inflammation, and oxidonitrergic flux. J. Biochem Mol. Toxicol. 2022 July 13, e23161.
  55. Ojetola, A.A., Asiwe, J.N., Adeyemi, W.J., Ogundipe, D.J., Fasanmade, A.A. Dietary Supplementation with D-Ribose-L-Cysteine Prevents Hepatic Stress and Pro-Inflammatory Responses in Male Wistar Rats Fed a High-Fructose High-Fat Diet. Pathophysiology 2022, 29, 631-639.
 
 
 

The Glutathione Man The Glutathione Story Glutathione Riboceine Max Products The Science Herbert T Nagasawa Max Research Team Users Testimonials Max Corporate Robert E Chan My Presentations FAQ Contact Us Beauty & Glamour Dr Robert H. Keller FusionExcel™

Malaysia

Contact me for the Best Prices & Delivery Options (I ship Worldwide)
Singapore

Max’s products are not intended for use in the cure,
mitigation, treatment or prevention of any disease

Today is

Visit counter For Websites  
 page views have been made on this website
 

Make Payment with PayPal (No Handling Charge)

Payment using Western Union Money Transfer

Payment with PayPal (No Handling Charge)

Other Money Transfer also acceptable

 

You are directed to view my Terms and Conditions of Use and Our Privacy Policy
Copyright © 1994–2026 The Glutathione Man - Robert E Chan. Serving you since 1994. All Rights Reserved.
The publication, reproduction, or distribution of any content on this website is strictly prohibited. All materials, including reports, images and logos, are my intellectual property. No part of this website may be copied, reproduced, modified, published, displayed, or used for commercial or other purposes without my prior written consent.
This webpage was updated on Monday, 19 January 2026