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Robert E Chan |
The Enchanting Journey begins
Unveiling the Fascinating History and Multifaceted Wonders of
Glutathione
In the intricate tapestry of human health, a silent protagonist
diligently operates in the background, diligently guarding our
cells and nurturing our overall well-being. This unassuming yet
extraordinary molecule serves as a master key to an astonishing
array of biological functions that profoundly shape our
vitality.
Allow me to guide you through a captivating exploration of "The
Glutathione Story," a voyage that traverses time and scientific
discovery, revealing the extraordinary journey of this unsung hero
within our bodies.
Through the many chapters of "The Glutathione Story," we will
navigate its influence on immunity, cellular revitalization, and its
potential to bridge the gap between health and longevity. This
is more than a mere narrative - it is a narrative of empowerment, a
remarkable saga of cellular resilience and strength, and an
exploration of the remarkable potential within our own bodies. Stay
tuned for the unfolding chapters that promise to shed light on the
awe-inspiring Glutathione Story.
Additional reference
https://www.theglutathioneman.com/about_me.htm
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Joseph de REY-PAILHADE |
The Glutathione Story – 1
The Discovery of Glutathione
Joseph de REY-PAILHADE (1850-1934?)
de Rey-Paihade was born in Paris, France, in 1850. He studied chemistry at the École Polytechnique and the École de Pharmacie in Paris. After
graduating, he worked as a chemist at the Pasteur Institute.
In 1888, de Rey-Paihade was studying the metabolism of yeast when he
isolated a compound that he called "philothion." Philothion is the
Greek word for "love of sulfur," and Rey-Paihade named the compound
after its sulfur-containing amino acids.
de Rey-Paihade's discovery of
Glutathione was a significant breakthrough in the field of
biochemistry. Glutathione is now known to be a major antioxidant in
the body, and it plays a vital role in many important biological
processes, including cell signalling, DNA repair, and immune
function.
de
Rey-Paihade continued to study Glutathione throughout his career. He
published several papers on the compound, and he also developed
methods for its purification and analysis.
de
Rey-Paihade died in Paris in 1934. His work on Glutathione laid the
foundation for much of the research that has been done on this
important molecule in the years since.
In addition to his work on Glutathione, de Rey-Paihade also made
significant contributions to the fields of organic chemistry and
pharmacology. He was a gifted chemist and a dedicated researcher,
and his work has had a lasting impact on the field of biochemistry.
Additional reference
https://openlibrary.org/authors/OL7173955A/Joseph_de_Rey-Pailhade |
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Sir Frederick Gowland Hopkins |
The Glutathione Story – 2
Glutathione's tripeptide chemical structure rediscovered
Sir Frederick Gowland Hopkins (1861 – 1947)
In a remarkable turn of events in 1921, 33 years
after its initial discovery, Glutathione once again found itself
in the spotlight, thanks to the pioneering efforts of Sir
Frederick Gowland Hopkins, an eminent English biochemist, and
the revered "Father of Biochemistry" from Cambridge University.
Sir Frederick Gowland Hopkins made a profound breakthrough by
"rediscovering" the substance's intricate structures and
unravelling its metabolic pathways.
Driven by an insatiable curiosity about the complexities of
biochemical processes within the human body, Sir Frederick
Gowland Hopkins embarked on a journey of scientific inquiry that
led him to the profound realization of the significance of
Glutathione. His seminal research not only shed light on the
tripeptide's chemical structures but also illuminated its
critical roles in various cellular processes.
Inspired by the molecule's unique
chemical composition, Sir Frederick Gowland Hopkins was
determined to give it a name that would reflect its
importance and newfound understanding. In 1929, he
christened the molecule "Glutathione," derived from the
amino acids that compose its structure—glutamic acid, cysteine,
and glycine. This name change cemented the molecule's identity
and marked a turning point in our understanding of its
significance in cellular health and overall well-being.
Sir Frederick Gowland Hopkins was awarded
the Nobel Prize in Physiology or Medicine in 1929, with
Christiaan Eijkman, for the discovery of vitamins. He also
discovered the amino acid tryptophan, in 1901. He was President
of the Royal Society from 1930 to 1935
The findings of Sir Frederick Gowland
Hopkins, published in THE JOURNAL OF BIOLOGICAL CHEMISTRY,
became a cornerstone of modern biochemistry and contributed
significantly to the growing body of knowledge on Glutathione.
His rediscovery and renaming of the molecule brought it into the
limelight once again, sparking renewed interest and further
exploration into its diverse roles in human physiology.
Additional reference
https://en.wikipedia.org/wiki/Frederick_Gowland_Hopkins
http://tinyurl.com/44ktz7a4
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Sir Charles Robert Harington |
The
Glutathione Story – 3
The Synthesis of Glutathione
Sir Charles Robert Harington (1897 – 1972) and Thomas Hobson
Mead
were involved in submitting a paper titled "Synthesis of
Glutathione" in 1935 to the Biochemical Journal when they were
affiliated with The Department of Pathological Chemistry at
University College Hospital Medical School in London.
Charles Robert Harington's contributions
to the field of immunochemistry and Thomas Hobson Mead's (a
British Biochemist) co-authorship in the publication of the
“Synthesis of Glutathione” demonstrate their involvement in
significant research related to this important molecule.
Their work on Glutathione and its synthesis undoubtedly added to
the scientific understanding of this tripeptide and its role in
various biochemical processes. Both Harington and Mead's
contributions have likely played a crucial role in advancing the
study of Glutathione and its broader implications in
biochemistry and medicine.Additional reference
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266669/
https://jamanetwork.com/journals/jama/article-abstract/1155102
https://thepeerage.com/p43206.htm
http://tinyurl.com/yuyvybmu
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Dr. Alton Meister |
The
Glutathione Story – 4
The Chemistry of Glutathione
Dr. Alton Meister (1922 – 1995)
In 1954, a groundbreaking chapter in the story of Glutathione
unfolded with the involvement of Dr. Alton Meister, a
distinguished Harvard graduate and an accomplished medical
doctor trained at Cornell Medical College in New York. Dr.
Meister, driven by a passion for scientific exploration,
assembled a team of dedicated researchers to embark on further
studies of this remarkable tripeptide.Over the span of more than two decades,
from 1954 until the 1980s, Dr. Meister and his devoted science
team delved deep into the intricacies of Glutathione's functions
and its potential implications for human health. Their research
efforts led to groundbreaking discoveries, shedding new light on
the molecule's mechanisms and its significance in cellular
physiology.
Dr. Meister's studies revealed the pivotal roles of Glutathione
in maintaining cellular redox balance, detoxification, and
supporting the body's antioxidant defence systems. Their work
provided a comprehensive understanding of Glutathione's
interactions with various enzymes and its impact on crucial
cellular processes.
The results of Dr. Meister's research, published in numerous
scientific journals, contributed significantly to the growing
body of knowledge on Glutathione. Their work underscored the
tripeptide's status as a key player in cellular health and its
implications for a wide range of health conditions.
Additional reference
https://library.weill.cornell.edu/sites/default/files/meister_0.pdf
https://en.wikipedia.org/wiki/Alton_Meister
https://www.nasonline.org/member-directory/deceased-members/52647.html
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Dr. Shelly C. Lu |
The
Glutathione Story – 5
Glutathione metabolism research
Dr. Shelly C. Lu
is a board-certified hepatologist and the Director of the Liver
Center at Cedars-Sinai Medical Center in Los Angeles,
California. She has been studying Glutathione for over 30 years,
and her research has focused on the role of Glutathione in liver
disease.
Lu's research has shown that
Glutathione plays a key role in protecting the liver from damage
caused by toxins and infections. It also helps to repair damage
that has already occurred. Glutathione levels are often low in
people with liver disease, and supplementation with Glutathione
can help to improve liver function.
Lu is a highly respected scientist who has made significant
contributions to the field of Glutathione research. Her work has
helped to shed light on the importance of Glutathione for liver
health and has also helped to develop new strategies for
preventing and treating liver disease.
Here are some of the key publications of Dr. Shelly C. Lu on
Glutathione:
Lu, S. C., & Mato, J. M. (2006). Glutathione and liver disease.
Journal of Hepatology, 44(1), 13-25.
Lu, S. C., & Jia, L. (2010). Glutathione and its role in aging
and age-related diseases. Ageing Research Reviews, 9(1), 1-11.
Lu, S. C., & Bosco, D. (2016). Glutathione and neurodegenerative
diseases. Frontiers in Pharmacology, 7, 119.
Lu stands as a pioneering figure in the realms of S-adenosylmethionine
and Glutathione metabolism research, with an illustrious
30-year-long career dedicated to unravelling the complexities of
these critical pathways. Her unwavering dedication and
groundbreaking contributions have earned her continuous funding
from the prestigious National Institutes of Health (NIH) since
1992, affirming her position at the forefront of scientific
exploration.
At the core of Dr. Lu's research lies an unwavering commitment
to elucidating the molecular intricacies governing fatty liver,
liver injury, and liver cancer, encompassing both primary and
metastatic forms. Her extensive research programs, generously
supported by NIH grants, have propelled our understanding of
these conditions, paving the way for potential breakthroughs in
diagnosis, management, and treatment strategies.
A hallmark of Dr. Lu's exceptional work lies in the
translational implications of her research. By skillfully
analysing her findings, she has successfully identified
potential biomarkers that distinguish simple fatty liver from
the more severe non-alcoholic steatohepatitis. This invaluable
distinction holds profound implications for early detection and
enhanced therapeutic approaches to liver-related disorders,
significantly impacting patient outcomes.
Beyond her contributions to fatty liver research, Dr. Lu's
endeavours extend to exploring effective agents for combating
liver and colon cancer. Her studies hold the promise of
inspiring novel therapeutic approaches that could revolutionize
cancer treatment, offering hope for improved survival rates and
enhanced quality of life for patients confronting these
challenging diseases.
One of Dr. Shelly Lu's standout achievements is her role as the
Principal Investigator (PI) in an NIH-funded clinical trial
investigating the therapeutic efficacy of S-adenosylmethionine
in patients with alcoholic cirrhosis. This pioneering clinical
trial marks a crucial step towards understanding the potential
benefits of S-adenosylmethionine in liver-related diseases,
hinting at the possibility of transformative treatments on the
horizon.
Dr. Lu's dedication to scientific excellence and her profound
contributions to S-adenosylmethionine and Glutathione metabolism
research have earned her widespread recognition and admiration
in the scientific community. Her trailblazing work continues to
inspire and ignite advancements in our comprehension of these
crucial pathways, with the ultimate aim of enhancing human
health and fostering improved patient outcomes. Through her
tireless pursuit of knowledge, Dr. Shelly Lu's legacy
reverberates as a beacon of hope in the quest to unlock the full
potential of Glutathione and S-adenosylmethionine for the
betterment of humanity.
Additional reference
https://researchers.cedars-sinai.edu/Shelly.Lu
https://www.cedars-sinai.org/provider/shelly-lu-897740.html
http://tinyurl.com/58vftdrx
http://tinyurl.com/5n6fex7k
https://scholar.google.com/citations?user=1KbroYEAAAAJ&hl=en
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Dr. Robert H Keller |
The
Glutathione Story - 6
Glutathione
Precursor as an alternative to Glutathione Supplement
Dr. Robert H. Keller (1942 – 2009)
A trailblazing scientist, physician, and educator renowned for
his groundbreaking contributions to Glutathione research.
Dr. Keller began working on a supplement
to raise intracellular glutathione levels in 1996 and was
awarded a Composition Patent in 2001 for his scientific
breakthrough product - a Glutathione Precursor Composition
combined with N-acetyl Cysteine (NAC). He began marketing MaxGXL™
through Max International LLC in 2006 amplifying intracellular
Glutathione level increase by an astounding 276%.
A triple board-certified physician, he earned acclaim as one of
America's Top Physicians (2003-2008) in Internal Medicine,
Immunology, and Haematology. He was also recognized among the
world’s Top 2,000 Outstanding Scientists.
While Dr. Keller's physical presence departed in 2009, his
impact endures. His MaxGXL™ / Original Glutathione Formula (OGF)
stands as a testament to his enduring legacy. Acknowledged as a
luminary in Glutathione research, Dr. Keller's profound insights
have revealed the multifaceted roles of Glutathione in
maintaining human health.
His illustrious career focused on unravelling the complexities
of this tripeptide molecule. Dr. Keller's pioneering studies
underscored Glutathione's pivotal role in shielding cells from
oxidative damage, a critical defence against age-related
diseases, cardiovascular issues, and neurodegenerative
conditions.
Beyond groundbreaking formulations that boost Glutathione
production, Dr. Keller's research delved into its role in
fortifying the immune system. By enhancing the body's ability to
combat pathogens, Glutathione emerged as a powerful ally,
bolstering optimal immune function. Dr.
Keller's impact extends beyond the lab. His commitment to
educating and empowering others in Glutathione research is
commendable. Through mentorship, he inspired scientists and
healthcare professionals to explore Glutathione's therapeutic
applications.
In an era dominated by oxidative stress and environmental
toxins, Dr. Keller's work gains heightened significance. By
highlighting Glutathione's role in maintaining cellular health
and countering free radicals, he has paved the way for
advancements in medical treatments and preventive healthcare
strategies. Dr. Keller's legacy continues to shape the landscape
of Glutathione research, offering a beacon of hope for those
seeking health solutions.
Additional reference
http://tinyurl.com/mu7dterp
https://tinyurl.com/3hm2tuda
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Dr. Herbert T. Nagasawa and Robert E Chan |
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The
Glutathione Story – 7
The Riboceine Invention - a precursor to Glutathione synthesis
Dr. Herbert T. Nagasawa
is a renowned
Glutathione researcher who has made significant contributions to
the understanding of this critical antioxidant and its diverse
applications in human health. His pioneering work has shed light
on the multifaceted roles of Glutathione in cellular protection,
detoxification, and its potential therapeutic benefits. Dr.
Nagasawa's career has been dedicated to unravelling the
intricacies of this tripeptide molecule. His groundbreaking
discoveries have elucidated the importance of Glutathione in
neutralizing harmful free radicals and reactive oxygen species,
which can contribute to various diseases, including cancer,
neurodegenerative disorders, and cardiovascular conditions.
Dr. Nagasawa's notable
achievements include the development of a novel compound called
Riboceine, a precursor to Glutathione synthesis. Riboceine
exhibits exceptional efficacy in boosting cellular Glutathione
levels, thereby enhancing the body's natural defense against
oxidative stress and supporting overall well-being. His research
has extended to exploring the potential of Glutathione and its
derivatives in addressing specific health challenges. His
studies have shown promise in using Glutathione-based therapies
for conditions such as liver diseases, inflammatory disorders,
and even certain types of cancer.
Dr. Nagasawa's work assumes even
greater significance as the impact of oxidative stress on
various health conditions becomes increasingly evident. By
advancing our understanding of Glutathione and its intricate
mechanisms, he has paved the way for potential therapeutic
interventions that could revolutionize medical treatments and
preventive care. Dr. Nagasawa's contributions as a Glutathione
researcher have been transformative. His dedication to
scientific exploration and his passion for improving human
health have propelled the field of Glutathione research to new
heights. Through his groundbreaking discoveries, he has given us
valuable insights into the immense potential of Glutathione as a
vital factor in promoting wellness and longevity.
Additional reference
https://www.researchgate.net/profile/Herbert-Nagasawa
https://patents.justia.com/inventor/herbert-t-nagasawa
https://www.theglutathioneman.com/Herbert_T_Nagasawa.htm
https://www.livemax.com/blog/dr-herbert-t-nagasawa-pioneer-of-riboceine/
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Jeanette C. Roberts, PhD., M.P.H. |
The
Glutathione Story – 8
Proof of concept for Riboceine
Jeanette C. Roberts, PhD., M.P.H.
Jeanette C. Roberts obtained her B.S. in Biochemistry from
Albright College, Pennsylvania, and a Doctorate in Medicinal
Chemistry from the University of Minnesota. With a
remarkable career, she spent fifteen years at the University
of Utah College of Pharmacy, four years as a professor at
the University of Wisconsin's Pharmaceutical Sciences
Division, and eleven years as Dean of the School of Pharmacy
at UW. Notably, she directed the UW Madison Center for
Interprofessional Practice and Education.
During her graduate years, Dr. Roberts
collaborated with Dr. Herbert T. Nagasawa, focusing on
RiboCeine™ in her doctoral thesis. As a professor emeritus
at the University of Wisconsin-Madison College of Pharmacy,
her research delves into Glutathione-derived APAP
metabolites' potential involvement in APAP nephrotoxicity.
She has explored the time course of Glutathione elevation in
various organs of L1210-bearing CDF1 mice using the L-Cysteine
prodrug. Additionally, she played a pivotal role in
providing the necessary precursor for Glutathione
biosynthesis.
In a YouTube video, Roberts enlightens
viewers about Glutathione and Riboceine™, a product
intricately designed to bolster Glutathione production.
Glutathione, recognized as the master antioxidant within
cells, safeguards cellular health by combatting toxins, free
radicals, and oxidative stress. Elevated Glutathione levels
correlate with enhanced physical health in the elderly
population. Research under Dr. Roberts has explored
Glutathione's impact on various health conditions, including
alcoholism, diabetes mellitus, environmental health, gout,
ophthalmology, and genomics. Dive into the profound insights
shared by this distinguished researcher on the forefront of
Glutathione studies.
Additional reference
https://apps.pharmacy.wisc.edu/facstaff/sciences/cvs/robertscv.pdf
https://apps.pharmacy.wisc.edu/sopdir/jeanette_roberts/
https://uawards.umn.edu/recipients-outstanding-achievement-award/jeanette-c-roberts
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Scott G
Nagasawa and Robert E Chan |
The Glutathione Story – 9
Dr. Scott G. Nagasawa
brings a wealth of experience to his role as Executive
Director of Product Research at Max International. With
a distinguished background, including his tenure as
Senior Vice President of Research and Development at
Shaklee Corporation, Dr. Nagasawa has been instrumental
in the development of numerous successful products in
the health and wellness industry.
Collaborating with partners such as Stuart Nagasawa, M.D.,
Scott Momii, and Dr. Herbert T. Nagasawa, Dr. Nagasawa
co-founded Cellgevity, a groundbreaking product designed
to support Glutathione production. This venture marked a
significant milestone in Glutathione research,
culminating in the creation of Max International's
flagship supplement known for its exceptional health
benefits.
Dr. Nagasawa's academic accomplishments, including a
Doctor of Pharmacy degree from the University of
Southern California (USC), coupled with his roles as
Director of Pharmaceutical Services and Clinical
Instructor at a leading teaching hospital, underscore
his commitment to advancing pharmaceutical sciences and
educating future healthcare professionals.
Driven by a passion for research and education, Dr.
Nagasawa continues to push the boundaries of Glutathione
research, leveraging his expertise to contribute to the
development of innovative products and furthering our
understanding of this vital antioxidant's impact on
human health. Through his leadership at Max
International and entrepreneurial endeavours, Dr.
Nagasawa remains at the forefront of Glutathione
research, paving the way for groundbreaking discoveries
and practical applications in the field of health and
wellness.
Additional reference
https://www.theglutathioneman.com/Research_Team.htm
https://www.mymaxoffice.com/company/why-max/science/#research_team_section
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Scott Momii |
The Glutathione Story
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Scott Momii
Scott Momii serves as the
Executive Director for Product Management at Max, a
company dedicated to spreading the benefits of
Glutathione enhancement globally. He emphasizes
Glutathione's role as a paramount antioxidant,
safeguarding cellular health by combatting toxins,
free radicals, and oxidative stress.
As we age, our
Glutathione levels decline, posing challenges to
maintaining optimal health. Scott collaborates with
luminaries like Dr. Stuart Nagasawa, Scott Nagasawa,
Pharm.D., and Dr. Herbert T Nagasawa in creating
Cellgevity, a groundbreaking product aimed at
supporting Glutathione production.
Scott's
journey intertwines scientific inquiry, business
acumen, and a dedication to well-being. With a B.A.
from San Jose State University and an M.B.A. from
Boston University, he lays a solid foundation
merging scientific understanding with business
acumen. His global perspective expands through a
summer program at Sophia University in Tokyo,
fostering cross-cultural insights into international
business practices.
Scott's
versatile career spans diverse industries, enriching
his prowess in Glutathione research. As General
Manager of a specialty chemicals company and
Director of Operations for a biotechnology firm, he
honed his expertise in scientific innovation,
project management, and health improvement. His
multifaceted role encompassed vital aspects like
manufacturing, quality control, sales, marketing,
and customer service, enriching his understanding of
successful research and development processes.
Scott’s wealth
of knowledge and expertise propels Max
International's mission to advance Glutathione
research and pioneer cutting-edge products.
Additional Reference:
https://patents.justia.com/inventor/scott-momii
https://www.theglutathioneman.com/Research_Team.htm
https://www.youtube.com/watch?v=1ZOZcrW-CMg
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