Dr Herbert T Nagasawa and Robert E Chan

The Glutathione Man


The Glutathione Story
The Glutathione Man

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The Enchanting Journey begins
Unveiling the Fascinating History and Multifaceted Wonders of Glutathione

In the intricate tapestry of human health, a silent protagonist diligently operates in the background, diligently guarding our cells and nurturing our overall well-being. This unassuming yet extraordinary molecule serves as a master key to an astonishing array of biological functions that profoundly shape our vitality.

Robert E Chan

Allow me to guide you through a captivating exploration of "The Glutathione Story," a voyage that traverses time and scientific discovery, revealing the extraordinary journey of this unsung hero within our bodies.

Through the many chapters of "The Glutathione Story," we will navigate its influence on immunity, cellular revitalization, and its potential to bridge the gap between health and longevity.  This is more than a mere narrative - it is a narrative of empowerment, a remarkable saga of cellular resilience and strength, and an exploration of the remarkable potential within our own bodies. Stay tuned for the unfolding chapters that promise to shed light on the awe-inspiring Glutathione Story.

Additional reference

The Glutathione Story – 1
The Discovery of Glutathione
Joseph de REY-PAILHADE (1850-1934?)

de Rey-Paihade was born in Paris, France, in 1850. He studied chemistry at the École Polytechnique and the École de Pharmacie in Paris. After graduating, he worked as a chemist at the Pasteur Institute.

In 1888, de Rey-Paihade was studying the metabolism of yeast when he isolated a compound that he called "philothion." Philothion is the Greek word for "love of sulfur," and Rey-Paihade named the compound after its sulfur-containing amino acids.


de Rey-Paihade's discovery of Glutathione was a significant breakthrough in the field of biochemistry. Glutathione is now known to be a major antioxidant in the body, and it plays a vital role in many important biological processes, including cell signalling, DNA repair, and immune function.
de Rey-Paihade continued to study Glutathione throughout his career. He published several papers on the compound, and he also developed methods for its purification and analysis.

de Rey-Paihade died in Paris in 1934. His work on Glutathione laid the foundation for much of the research that has been done on this important molecule in the years since.
In addition to his work on Glutathione, de Rey-Paihade also made significant contributions to the fields of organic chemistry and pharmacology. He was a gifted chemist and a dedicated researcher, and his work has had a lasting impact on the field of biochemistry.
Additional reference

The Glutathione Story – 2
Glutathione's tripeptide chemical structure rediscovered
Sir Frederick Gowland Hopkins (1861 – 1947)

In a remarkable turn of events in 1921, 33 years after its initial discovery, Glutathione once again found itself in the spotlight, thanks to the pioneering efforts of Sir Frederick Gowland Hopkins, an eminent English biochemist, and the revered "Father of Biochemistry" from Cambridge University.

Sir Frederick Gowland Hopkins made a profound breakthrough by "rediscovering" the substance's intricate structures and unravelling its metabolic pathways.

Driven by an insatiable curiosity about the complexities of biochemical processes within the human body, Sir Frederick Gowland Hopkins embarked on a journey of scientific inquiry that led him to the profound realization of the significance of Glutathione. His seminal research not only shed light on the tripeptide's chemical structures but also illuminated its critical roles in various cellular processes.

Sir Frederick Gowland Hopkins

Inspired by the molecule's unique chemical composition, Sir Frederick Gowland Hopkins was determined to give it a name that would reflect its importance and newfound understanding. In 1929, he christened the molecule "Glutathione," derived from the amino acids that compose its structure—glutamic acid, cysteine, and glycine. This name change cemented the molecule's identity and marked a turning point in our understanding of its significance in cellular health and overall well-being.

Sir Frederick Gowland Hopkins was awarded the Nobel Prize in Physiology or Medicine in 1929, with Christiaan Eijkman, for the discovery of vitamins. He also discovered the amino acid tryptophan, in 1901. He was President of the Royal Society from 1930 to 1935

The findings of Sir Frederick Gowland Hopkins, published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, became a cornerstone of modern biochemistry and contributed significantly to the growing body of knowledge on Glutathione. His rediscovery and renaming of the molecule brought it into the limelight once again, sparking renewed interest and further exploration into its diverse roles in human physiology.

Additional reference

The Glutathione Story – 3
The Synthesis of Glutathione
Sir Charles Robert Harington (1897 – 1972) and Thomas Hobson Mead

were involved in submitting a paper titled "Synthesis of Glutathione" in 1935 to the Biochemical Journal when they were affiliated with The Department of Pathological Chemistry at University College Hospital Medical School in London.

Sir Charles Robert Harington

Charles Robert Harington's contributions to the field of immunochemistry and Thomas Hobson Mead's (a British Biochemist) co-authorship in the publication of the “Synthesis of Glutathione” demonstrate their involvement in significant research related to this important molecule.

Their work on Glutathione and its synthesis undoubtedly added to the scientific understanding of this tripeptide and its role in various biochemical processes. Both Harington and Mead's contributions have likely played a crucial role in advancing the study of Glutathione and its broader implications in biochemistry and medicine.
Additional reference

The Glutathione Story – 4
The Chemistry of Glutathione
Dr. Alton Meister (1922 – 1995)

In 1954, a groundbreaking chapter in the story of Glutathione unfolded with the involvement of Dr. Alton Meister, a distinguished Harvard graduate and an accomplished medical doctor trained at Cornell Medical College in New York. Dr. Meister, driven by a passion for scientific exploration, assembled a team of dedicated researchers to embark on further studies of this remarkable tripeptide.

Dr. Alton Meister

Over the span of more than two decades, from 1954 until the 1980s, Dr. Meister and his devoted science team delved deep into the intricacies of Glutathione's functions and its potential implications for human health. Their research efforts led to groundbreaking discoveries, shedding new light on the molecule's mechanisms and its significance in cellular physiology.

Dr. Meister's studies revealed the pivotal roles of Glutathione in maintaining cellular redox balance, detoxification, and supporting the body's antioxidant defence systems. Their work provided a comprehensive understanding of Glutathione's interactions with various enzymes and its impact on crucial cellular processes.

The results of Dr. Meister's research, published in numerous scientific journals, contributed significantly to the growing body of knowledge on Glutathione. Their work underscored the tripeptide's status as a key player in cellular health and its implications for a wide range of health conditions.
Additional reference

The Glutathione Story – 5
Glutathione metabolism research
Dr. Shelly C. Lu

is a board-certified hepatologist and the Director of the Liver Center at Cedars-Sinai Medical Center in Los Angeles, California. She has been studying Glutathione for over 30 years, and her research has focused on the role of Glutathione in liver disease.

Dr. Shelly C. Lu

Lu's research has shown that Glutathione plays a key role in protecting the liver from damage caused by toxins and infections. It also helps to repair damage that has already occurred. Glutathione levels are often low in people with liver disease, and supplementation with Glutathione can help to improve liver function.

Lu is a highly respected scientist who has made significant contributions to the field of Glutathione research. Her work has helped to shed light on the importance of Glutathione for liver health and has also helped to develop new strategies for preventing and treating liver disease.

Here are some of the key publications of Dr. Shelly C. Lu on Glutathione:
Lu, S. C., & Mato, J. M. (2006). Glutathione and liver disease. Journal of Hepatology, 44(1), 13-25.
Lu, S. C., & Jia, L. (2010). Glutathione and its role in aging and age-related diseases. Ageing Research Reviews, 9(1), 1-11.
Lu, S. C., & Bosco, D. (2016). Glutathione and neurodegenerative diseases. Frontiers in Pharmacology, 7, 119.

Lu stands as a pioneering figure in the realms of S-adenosylmethionine and Glutathione metabolism research, with an illustrious 30-year-long career dedicated to unravelling the complexities of these critical pathways. Her unwavering dedication and groundbreaking contributions have earned her continuous funding from the prestigious National Institutes of Health (NIH) since 1992, affirming her position at the forefront of scientific exploration.

At the core of Dr. Lu's research lies an unwavering commitment to elucidating the molecular intricacies governing fatty liver, liver injury, and liver cancer, encompassing both primary and metastatic forms. Her extensive research programs, generously supported by NIH grants, have propelled our understanding of these conditions, paving the way for potential breakthroughs in diagnosis, management, and treatment strategies.

A hallmark of Dr. Lu's exceptional work lies in the translational implications of her research. By skillfully analysing her findings, she has successfully identified potential biomarkers that distinguish simple fatty liver from the more severe non-alcoholic steatohepatitis. This invaluable distinction holds profound implications for early detection and enhanced therapeutic approaches to liver-related disorders, significantly impacting patient outcomes.

Beyond her contributions to fatty liver research, Dr. Lu's endeavours extend to exploring effective agents for combating liver and colon cancer. Her studies hold the promise of inspiring novel therapeutic approaches that could revolutionize cancer treatment, offering hope for improved survival rates and enhanced quality of life for patients confronting these challenging diseases.

One of Dr. Shelly Lu's standout achievements is her role as the Principal Investigator (PI) in an NIH-funded clinical trial investigating the therapeutic efficacy of S-adenosylmethionine in patients with alcoholic cirrhosis. This pioneering clinical trial marks a crucial step towards understanding the potential benefits of S-adenosylmethionine in liver-related diseases, hinting at the possibility of transformative treatments on the horizon.

Dr. Lu's dedication to scientific excellence and her profound contributions to S-adenosylmethionine and Glutathione metabolism research have earned her widespread recognition and admiration in the scientific community. Her trailblazing work continues to inspire and ignite advancements in our comprehension of these crucial pathways, with the ultimate aim of enhancing human health and fostering improved patient outcomes. Through her tireless pursuit of knowledge, Dr. Shelly Lu's legacy reverberates as a beacon of hope in the quest to unlock the full potential of Glutathione and S-adenosylmethionine for the betterment of humanity.
Additional reference
https://www.cedars-sinai.edu/research/news/cedars-science/2021/shelly-lu-md-wins-prism-award.html https://scholar.google.com/citations?user=1KbroYEAAAAJ&hl=en 

The Glutathione Story - 6 Glutathione
Precursor as an alternative to Glutathione Supplement
Dr. Robert H. Keller (1942 – 2009)

A trailblazing scientist, physician, and educator renowned for his groundbreaking contributions to Glutathione research.

Dr. Robert H Keller

Dr. Keller began working on a supplement to raise intracellular glutathione levels in 1996 and was awarded a Composition Patent in 2001 for his scientific breakthrough product - a Glutathione Precursor Composition combined with N-acetyl Cysteine (NAC). He began marketing MaxGXL™ through Max International LLC in 2006 amplifying intracellular Glutathione level increase by an astounding 276%.

A triple board-certified physician, he earned acclaim as one of America's Top Physicians (2003-2008) in Internal Medicine, Immunology, and Haematology. He was also recognized among the world’s Top 2,000 Outstanding Scientists.

While Dr. Keller's physical presence departed in 2009, his impact endures. His MaxGXL™ / Original Glutathione Formula (OGF) stands as a testament to his enduring legacy. Acknowledged as a luminary in Glutathione research, Dr. Keller's profound insights have revealed the multifaceted roles of Glutathione in maintaining human health.

His illustrious career focused on unravelling the complexities of this tripeptide molecule. Dr. Keller's pioneering studies underscored Glutathione's pivotal role in shielding cells from oxidative damage, a critical defence against age-related diseases, cardiovascular issues, and neurodegenerative conditions.

Beyond groundbreaking formulations that boost Glutathione production, Dr. Keller's research delved into its role in fortifying the immune system. By enhancing the body's ability to combat pathogens, Glutathione emerged as a powerful ally, bolstering optimal immune function. Dr.

Keller's impact extends beyond the lab. His commitment to educating and empowering others in Glutathione research is commendable. Through mentorship, he inspired scientists and healthcare professionals to explore Glutathione's therapeutic applications.

In an era dominated by oxidative stress and environmental toxins, Dr. Keller's work gains heightened significance. By highlighting Glutathione's role in maintaining cellular health and countering free radicals, he has paved the way for advancements in medical treatments and preventive healthcare strategies. Dr. Keller's legacy continues to shape the landscape of Glutathione research, offering a beacon of hope for those seeking health solutions.
Additional reference


To be Continued....

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This webpage was updated on Sunday, 26 November 2023